N-(3,4-dichlorophenyl)alanine → 3-(N'-(3,4-Dichlorophenyl)-D,L-alaninyl)amino-epsilon-caprolactam

Participants

Reaction Steps

Following General Procedure A above using N-(3,4-dichlorophenyl)-D,L-alanine (Example Q) and 3-(S)-amino-ε-caprolactam (Sigma), the title compound was prepared as a solid having a melting point of 199° C. The reaction was monitored by tlc on silica gel (Rf=0.4 in 50% ethyl acetate/hexanes) and purification was by preparative thin layer chromatography using 50% ethyl acetate/hexanes as the eluant.

Provenance & Evidence