Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, (αS)- → HCID 131725174, compound

HRID 965750Notes

Reaction equation

HRID 965750 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([F:13])[CH:12]=1)[C@H:5]([OH:9])[C:6]([OH:8])=O.Cl.[NH2:15][C@H:16]([C:18]([CH:20]1[CH2:26][C:25]([CH3:28])([CH3:27])[C:24]([NH2:29])=[N:23][C:22]2[CH:30]=[CH:31][CH:32]([CH3:35])[C:33](=[O:34])[C:21]1=2)=[O:19])[CH3:17]>>[F:13][C:11]1[CH:10]=[C:4]([CH:3]=[C:2]([F:1])[CH:12]=1)[C@H:5]([OH:9])[C:6]([NH:15][C@H:16]([C:18]([CH:20]1[CH2:26][C:25]([CH3:28])([CH3:27])[C:24]([NH2:29])=[N:23][C:22]2[CH:30]=[CH:31][CH:32]([CH3:35])[C:33](=[O:34])[C:21]1=2)=[O:19])[CH3:17])=[O:8]

Participants

3

Reactant 2

HCID 6951479Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, (αS)-HCID 69269260HCID 69269260, compound

Product 1

HCID 131725174HCID 131725174, compound

Procedure

Following General Procedure D and using (S)-3,5-difluoromandelic acid (Example L) and 5-(L-alaninyl)-amino-3,3,7-trimethyl-5,7-dihydro-6H-benz[b]azepin-6-one hydrochloride (Example 6-B), the title compound was prepared. The product was purified by chromatography (silica, 3% MeOH/CHCl3).

Workup

  1. customThe product was purified by chromatography (silica, 3% MeOH/CHCl3)

Sources & evidence

ORD record
ord-cc76ff4078d84d7c8cebf4db483d9d4b
Source dataset
uspto-grants-2005_10
Patent number
US06951854B1

Reaction notes

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