HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyl iodide → 2,4-Dioxo-1,5-bis-(2-methylpropyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyl iodide | HCID 10556 | — |
| Reactant | 1H-1,5-Benzodiazepine-2,4(3H,5H)-dione | HCID 283534 | — |
| Product | 2,4-Dioxo-1,5-bis-(2-methylpropyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine | HCID 22312768 | — |
Reaction Steps
2,4-Dioxo-1,5-bis-(2-methylpropyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine was prepared following General Procedure 8-M using the product from Example 8-P, Step A and 1-iodo-2-methylpropane (Aldrich). Purification was by flash chromatography eluting with EtOAc/hexanes (3:7 gradient to 1:1), then recrystalization from EtOAc/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06951854B1 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-f5cb87ee00b349ca9c71da2c63e8a912 |
| Source note | uspto-grants-2005_10 |