Bromomethylcyclopropane → 2,4-Dioxo-1,5-bis-(cyclopropylmethyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Participants

Role	Name	HCID	Charge
Reactant	Bromomethylcyclopropane	HCID 81503	—
Reactant	1H-1,5-Benzodiazepine-2,4(3H,5H)-dione	HCID 283534	—
Product	2,4-Dioxo-1,5-bis-(cyclopropylmethyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine	HCID 22312482	—

Reaction Steps

2,4-Dioxo-1,5-bis-(cyclopropylmethyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine was prepared following General Procedure 8-M using the product from Example 8-P, Step A, and (bromomethyl)cyclopropane (Lancaster). Purification was by flash chromatography eluting with EtOAc/hexanes (3:7 gradient to straight EtOAc), then recrystalization from EtOAc/hexanes.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06951854B1
Source dataset	uspto-grants-2005_10
ORD ID	ord-ba6a25366a044944988fa6fc3a2f463e
Source note	uspto-grants-2005_10