HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl cyanoacetate → 6,7-Dihydroxy-2-imino-2H-chromene-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl cyanoacetate | HCID 7764 | — |
| Reactant | 2,4,5-Trihydroxybenzaldehyde | HCID 643387 | — |
| Catalyst | Acetic Acid | HCID 176 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6,7-Dihydroxy-2-imino-2H-chromene-3-carboxylic acid ethyl ester | HCID 136377625 | — |
Reaction Steps
To a solution of 2,4,5-trihydroxybenzaldehyde (2.94 g) and ethyl cyanoacetate (1.62 g) in DMF (20 ml) were added 20 drops (Pasteur pipette) of piperidine and eight drops of acetic acid and the solution kept at 80° C. under nitrogen for two hours. The product was filtered and washed with DMF and ethyl ether. Yield: 2.00 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06951870B2 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-3c8480c2150a4cc39986f0d6baa4f641 |
| Source note | uspto-grants-2005_10 |