HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 965786Generated: October 30, 2026
Acetic Acid → 6,7-Dihydroxy-3-(2H-tetrazol-5-yl)-chromen-2-one
https://huagongshe.com/reaction/965786
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Ethyl 1H-tetrazole-5-acetate | HCID 543616 | — |
| Reactant | 2,4,5-Trihydroxybenzaldehyde | HCID 643387 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6,7-Dihydroxy-3-(2H-tetrazol-5-yl)-chromen-2-one | HCID 135847950 | — |
Reaction Steps
A mixture of 2,4,5-trihydroxybenzaldehyde (1.23 g), (2H-tetrazol-5-yl)-acetic acid ethyl ester (1.25 g), piperidine (1.36 g) and acetic acid (0.06 g) in DMF (10 ml) was stirred at 90° C. under nitrogen for two hours. After ice water treatment and acidification to pH 2 the product was filtered and triturated with hot ethanol. Yield: 0.55 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06951870B2 |
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| Source dataset | uspto-grants-2005_10 |
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| ORD ID | ord-e5f95f22bf53429da2557a2b5f27f8cf |
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| Source note | uspto-grants-2005_10 |
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