反应详情

A mixture of benzyl [1-(3,3-dimethyl-2-oxobutyl)piperidin-4-yl]methylcarbamate (Step 1, 9.6 g, 27.7 mmol), 5% palladium on carbon (1.2 g) and acetic acid (4 mL) in ethanol (70 mL) was stirred at room temperature for 23 h under hydrogen atmosphere. Palladium on carbon was removed by filtration through a pad of Celite and the filtrate was concentrated. The residue was dissolved in ethyl acetate, washed with aqueous ammonia and extracted with ethyl acetate (5×50 mL). After dried over magnesium sulfate, removal of solvent gave the title compound (2.7 g, 46%) as a yellow oil.

1. customPalladium on carbon was removed by filtration through a pad of Celite
2. concentrationthe filtrate was concentrated
3. dissolutionThe residue was dissolved in ethyl acetate
4. washwashed with aqueous ammonia
5. extractionextracted with ethyl acetate (5×50 mL)
6. dry with materialAfter dried over magnesium sulfate, removal of solvent