1-Boc-4-(aminomethyl)piperidine → Tert-butyl 4-({[(5-amino-6-chloro-2-methylimidazo[1,2-a]pyridin-8-yl)carbonyl]amino}methyl)piperidine-1-carboxylate

HRID 965811Notes

Reaction equation

HRID 965811 reaction equation
C[C:2]1[N:6]2[C:7]([NH2:15])=[C:8]([Cl:14])[CH:9]=[C:10]([C:11]([OH:13])=O)[C:5]2=[N:4][C:3]=1[CH3:16].[NH2:17][CH2:18][CH:19]1[CH2:24][CH2:23][N:22]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:21][CH2:20]1>>[NH2:15][C:7]1[N:6]2[CH:2]=[C:3]([CH3:16])[N:4]=[C:5]2[C:10]([C:11]([NH:17][CH2:18][CH:19]2[CH2:24][CH2:23][N:22]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:21][CH2:20]2)=[O:13])=[CH:9][C:8]=1[Cl:14]

Participants

3

Reactant 2

HCID 7368171-Boc-4-(aminomethyl)piperidineHCID 67550158Methyl 5-amino-6-chloro-2-methylimidazo[1,2-a]pyridine-8-carboxylic acid

Product 1

HCID 22236490Tert-butyl 4-({[(5-amino-6-chloro-2-methylimidazo[1,2-a]pyridin-8-yl)carbonyl]amino}methyl)piperidine-1-carboxylate

Procedure

The title compound was prepared according to the procedure described in the step 3 of Example 4 from 5-amino-6-chloro-2-methylimidazo[1,2-a]pyridine-8-carboxilic acid (Example 2, Step 5) and tert-butyl 4-(aminomethyl)piperidine-1-carboxylate (J. Prugh, L. A. Birchenough and M. S. Egbertson, Synth. Commun., 1992, 22, 2357-60).

Sources & evidence

ORD record
ord-a0b6c6dd3d7f4f25ba069ba085ddbb91
Source dataset
uspto-grants-2005_10
Patent number
US06951867B2

Reaction notes

Loading…