Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chloroaniline → N-(4-chlorophenyl)piperidin-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chloroaniline | HCID 7812 | — |
| 반응물 | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Trifluoroacetic acid | HCID 6422 | — |
| 생성물 | N-(4-chlorophenyl)piperidin-4-amine | HCID 7183033 | — |
반응 단계
Was synthesised in the same way as (A) from 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (3.59 g, 18.0 mmol), 4-chloro-phenylamine (1.15 g, 9.0 mmol) and sodium triacetoxyborhydride (5.34 g, 25.2 mmol) in dichloromethane (40 ml) and acetic acid (3.1 ml). The deprotection was run in dichloromethane (37 ml) and trifluoro acetic acid (18 ml). Yield 1.5 g, 79%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06951874B2 |
| 출처 데이터셋 | uspto-grants-2005_10 |
| ORD ID | ord-aa69863d6b364afb9e8233d4be5564d3 |
| 출처 메모 | uspto-grants-2005_10 |