HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Chlorophenoxy)pyrrolidine → N-(2-{3-[3-(4-Chlorophenoxy)-1-pyrrolidinyl]-2-hydroxy-2-methylpropoxy}phenyl)acetamide Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Chlorophenoxy)pyrrolidine | HCID 12999570 | — |
| Reactant | N-{2-[(2-methyl-2-oxiranyl)methoxy]phenyl}acetamide | HCID 22386946 | — |
| Product | N-(2-{3-[3-(4-Chlorophenoxy)-1-pyrrolidinyl]-2-hydroxy-2-methylpropoxy}phenyl)acetamide Hydrochloride | HCID 22313690 | 221.3% |
Reaction Steps
The title compound (255 mg, 110%) was prepared from N-{2-[(2-methyl-2-oxiranyl)methoxy]phenyl}acetamide (123 mg, 0.557 mmol) and 3-(4-chlorophenoxy)pyrrolidine (100 mg, 0.506 mmol) analogously to that described in Example 1 (iii).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06951874B2 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-113afa7afa7649d2a2296b1994e752d8 |
| Source note | uspto-grants-2005_10 |