Hydrazine → HCID 22313799, compound

HRID 965942Notes

Reaction equation

HRID 965942 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH2:12][NH2:13]>C(O)C>[ClH:1].[ClH:1].[NH:12]([C:2]1[N:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1)[NH2:13]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 12015126-chloropyridine-3-sulfonamide

Product 1

HCID 22313799HCID 22313799, compoundYield 114%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 6-chloro-3-pyridinesulfonamide (0.64 g, 3.32 mmol) in ethanol (20 mL) was added hydrazine anhydrous (0.128 g, 3.99 mmol). After the reaction mixture was heated at reflux temperature for 5 hours, the solvent was removed. The residue was washed with methylene chloride to give the subtitle compound (0.494 g, 79.0% yield).

Workup

  1. temperatureAfter the reaction mixture was heated
  2. temperatureat reflux temperature for 5 hours
  3. customthe solvent was removed
  4. washThe residue was washed with methylene chloride

Sources & evidence

ORD record
ord-175fd2fa8c0b4a0883d9a4861e66dc0a
Source dataset
uspto-grants-2005_10
Patent number
US06951876B2

Reaction notes

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