1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 4-bromo-2-chloro-N-(2,2-diethoxyethyl)benzamide

Participants

Reaction Steps

To a suspension of 2-chloro-4-bromobenzoic acid (10.0 g, 42.47 mmol) in CH2Cl2 (1000 mL) was added aminoacetaldehyde diethyl acetal (5.1 mL, 46.72 mmol) and WSC (9.77 g, 50.96 mmol) at room temperature, and stirred for 4 hours. The mixture was washed with water (100 mL), dried over MgSO4. Removal of the solvent, gave title compound (14.88 g, 100% yield).

Provenance & Evidence