5-[5-(4-bromophenyl)-4-ethyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide → 5-{4-Ethyl-5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide

HRID 965962Notes

Reaction equation

HRID 965962 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([C:13]3[CH:14]=[CH:15][C:16]([S:19]([NH2:22])(=[O:21])=[O:20])=[N:17][CH:18]=3)[N:11]=[C:10]([C:23]([F:26])([F:25])[F:24])[C:9]=2[CH2:27][CH3:28])=[CH:4][CH:3]=1.BrC1C=CC(C2N([C:41]3C=C[C:44]([S:47](N)(=O)=O)=[N:45][CH:46]=3)N=C(C(F)(F)F)C=2Cl)=CC=1>>[CH2:27]([C:9]1[C:10]([C:23]([F:26])([F:25])[F:24])=[N:11][N:12]([C:13]2[CH:14]=[CH:15][C:16]([S:19]([NH2:22])(=[O:21])=[O:20])=[N:17][CH:18]=2)[C:8]=1[C:5]1[CH:6]=[CH:7][C:2]([C:46]2[N:45]=[CH:44][S:47][CH:41]=2)=[CH:3][CH:4]=1)[CH3:28]

Participants

3

Reactant 2

HCID 223137925-[5-(4-bromophenyl)-4-ethyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamideHCID 223138055-[5-(4-bromophenyl)-4-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide

Product 1

HCID 101627765-{4-Ethyl-5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide

Procedure

The title compound was prepared according to the procedure of step 3 in the Example 4 using 5-[5-(4-bromophenyl)-4-ethyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide, instead of 5-[5-(4-bromophenyl)-4-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide.

Sources & evidence

ORD record
ord-88621db0877744f39b9bb399dba69855
Source dataset
uspto-grants-2005_10
Patent number
US06951876B2

Reaction notes

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