Bromine → HCID 22313787, compound

HRID 965983Notes

Reaction equation

HRID 965983 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].[Br:12]Br>O1CCOCC1>[Br:12][CH2:10][C:9]([C:3]1[CH:4]=[CH:5][C:6]([OH:8])=[CH:7][C:2]=1[F:1])=[O:11]

Participants

4

Reactant 2

HCID 24408BromineHCID 27249122'-Fluoro-4'-hydroxyacetophenone

Product 1

HCID 22313787HCID 22313787, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a stirred solution of 1-(2-fluoro-4-hydroxyphenyl)-1-ethanone (2.56 g, 16.6 mmol) in dioxane (4 ml) was added a solution of bromine (2.70 g, 16.9 mmol) in dioxane (15 ml) dropwise, and the mixture was stirred at room temperature for 3 hours. The volatile was evaporated in vacuo, and the residue was used for next reaction without further purification. (2.4 g, 62% yield).

Workup

  1. customThe volatile was evaporated in vacuo
  2. customthe residue was used for next reaction without further purification

Sources & evidence

ORD record
ord-d64da69ff95b458fbe2a43961b510905
Source dataset
uspto-grants-2005_10
Patent number
US06951876B2

Reaction notes

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