反应详情

A solution of 5-bromo-2-methyl-4-nitroimidazole (5.0 g, 24 mmol), mesitylboric acid (3.96 g, 24 mmol), Pd(PPh3)4 (1.4 g, 1.2 mmol) and barium hydroxide octahydrate (19.1 g, 61 mmol) in 2,2-dimethoxyethane (150 mL) and water (25 mL) was heated at reflux for four hours. After filtered through Celite, the filtrate was diluted with ethyl acetate, washed with brine, dried over anhydrous magnesium sulfate and evaporated. The resulting crystals were washed with ethyl acetate, to give the title compound (4.17 g) as white crystals.

1. temperatureat reflux for four hours
2. filtrationAfter filtered through Celite
3. additionthe filtrate was diluted with ethyl acetate
4. washwashed with brine
5. dry with materialdried over anhydrous magnesium sulfate
6. customevaporated
7. washThe resulting crystals were washed with ethyl acetate