Water → HCID 135593028, compound

Participants

Reaction Steps

1.0 M tert-BuOK/THF (0.29 mL, 0.29 mmol) was added to a solution of 3-mesityl-2,5-dimethyl-7,8-dihydro-6H-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidine (80 mg, 0.261 mmol) prepared in Example 72 in THF (4 mL), which was at room temperature, followed by stirring at room temperature for 15 hours. Water was added, and the mixture was extracted with ethyl acetate, washed with brine, dried over MgSO4 and the solvent was evaporated. The residue was subjected to silica gel column cromatography (25% ethyl acetate/hexane), to give the title compound (50 mg, 63%) as white crystals.

Provenance & Evidence