Sodium Carbonate → HCID 22249963, compound

HRID 966041Notes

Reaction equation

HRID 966041 reaction equation
Cl[C:2]1[N:7]2[N:8]=[C:9]([CH3:20])[C:10]([C:11]3[C:16]([CH3:17])=[CH:15][C:14]([CH3:18])=[CH:13][C:12]=3[CH3:19])=[C:6]2[N:5]=[C:4]([CH3:21])[C:3]=1[CH2:22][CH2:23]Cl.NC(N)=[S:27].C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[C:16]1([CH3:17])[CH:15]=[C:14]([CH3:18])[CH:13]=[C:12]([CH3:19])[C:11]=1[C:10]1[C:9]([CH3:20])=[N:8][N:7]2[C:2]3[S:27][CH2:23][CH2:22][C:3]=3[C:4]([CH3:21])=[N:5][C:6]=12

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 2723790ThioureaHCID 22249724HCID 22249724, compound

Product 1

HCID 22249963HCID 22249963, compoundYield 97.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 7-chloro-6-(2-chloroethyl)-3-mesityl-2,5-dimethylpyrazolo[1,5-a]pyrimidine (500 mg,1.38 mmol), thiourea (105 mg, 1.38 mmol)and sodium carbonate (180 mg, 1.73 mmol) in ethanol (10 mL) was heated under reflux for one hour. After evaporating, water was added and the resulting crystals were collected by filtration. The crystals were washed with water, to give the title compound (436 mg) as white crystals.

Workup

  1. temperatureunder reflux for one hour
  2. customAfter evaporating
  3. additionwater was added
  4. filtrationthe resulting crystals were collected by filtration
  5. washThe crystals were washed with water

Sources & evidence

ORD record
ord-f6ad1b08cbab4dc4a63e4e3ed29f8abf
Source dataset
uspto-grants-2005_10
Patent number
US06951865B2

Reaction notes

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