3-Pentanamine → 1-(1-Ethylpropyl)-6-mesityl-4,8-dimethyl-2,3-dihydro-1H-imidazo[1,5-a]pyrrolo[3,2-e]pyrimidine

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Reaction Steps

A solution of 4-chloro-3-(2-chloroethyl)-8-mesityl-2,6-dimethylimidazo[1,5-a]pyrimidine (139 mg, 0.38 mmol) in 3-aminopentane (10 mL) was heated under reflux for five days. After evaporating, the residue was purified by dry pack silica gel column chromatography (25-40% ethyl acetate/hexane), to give the title compound (69 mg) as pale yellow crystals.

Provenance & Evidence