反应详情

Manganese dioxide (67 mg, 0.77 mmol) was added to a solution of 1-(1-ethylpropyl)-6-mesityl-4,8-dimethyl-2,3-dihydro-1H-imidazo[1,5-a]pyrrolo[3,2-e]pyrimidine (58 mg, 0.15 mmol) in toluene (10 mL), followed by heating under reflux for three days. After filtering through Celite, the mixture was evaporated. The residue was purified by silica gel column chromatography (30% ethyl acetate/hexane), to give the title compound (22 mg) as pale yellow crystals.

1. temperatureby heating
2. temperatureunder reflux for three days
3. filtrationAfter filtering through Celite
4. customthe mixture was evaporated
5. customThe residue was purified by silica gel column chromatography (30% ethyl acetate/hexane)