HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine → HCID 22314380, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | Indole, 3-acetyl-5-nitro- | HCID 20900 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 22314380 | HCID 22314380 | 99% |
Reaction Steps
A suspension of 3-acetyl-5-nitroindole (3.0 g, 14.7 mmol) and Raney Nickel (3.0 g) in methanol is treated dropwise with hydrazine (0.7 g, 21.9 mmol) at 0° C., stirred under N2 for 1 h and filtered. The filtrate is concentrated in vacuo to afford the title product as an oil, 2.5 g (99% yield) identified by NMR and mass spectral analyses.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06951881B2 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-ff282b7cd89b480790c0b7011fe70c52 |
| Source note | uspto-grants-2005_10 |