Sodium Carbonate → HCID 9978819, compound

Participants

Reaction Conditions

Reaction Steps

To a reaction flask charged with 14.7 mg (0.013 mmol) of tetrakis(triphenylphosphine)palladium(0) in ethylene glycol dimethyl ether (2.5 mL) under nitrogen was added 125 mg (0.27 mmol) of the product from Example 6. The resulting yellow solution was stirred for 10 min before the addition of 41.0 mg (0.32 mmol) of 3-thiopheneboronic acid dissolved in ethanol (0.2 mL) and the subsequent addition of 0.27 mL (0.54 mmol) of a 2 M sodium carbonate aqueous solution. The reaction mixture was heated at 80° C. for ˜20 h and then cooled to room temperature. The liquid was separated from the solid residue, and the residue was rinsed with dichloromethane, which was subsequently combined with the isolated liquid. The solvent was evaporated, and the crude product was partitioned between brine (˜4 mL) and dichloromethane (˜4 mL). The organic layer was washed with additional brine, dried over magnesium sulfate, and filtered. The solvent was evaporated, and the residue was purified by column chromatography (hexane/ethyl acetate) to yield 55 mg (50%) of the title compound.

Provenance & Evidence