4-Fluorobenzyl bromide → HCID 22314495, compound

HRID 966085Notes

Reaction equation

HRID 966085 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([OH:10])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[F:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16]Br)=[CH:14][CH:13]=1>>[F:1][C:2]1[CH:9]=[C:8]([O:10][CH2:16][C:15]2[CH:18]=[CH:19][C:12]([F:11])=[CH:13][CH:14]=2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Participants

3

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 27346752-Fluoro-4-hydroxybenzonitrile

Product 1

HCID 22314495HCID 22314495, compoundYield 100%

Procedure

As described for example 1a, 2-fluoro-4-hydroxy-benzonitrile (5.0 g, 36 mmol) [using 4-fluorobenzyl bromide instead of 3-fluorobenzyl bromide] was converted to the title compound (8.9 g, 100%) which was obtained as a white solid. MS: m/e=245.0 (M+).

Sources & evidence

ORD record
ord-c0b05c8f31ac4a9e8b6b4af2a589bffe
Source dataset
uspto-grants-2005_10
Patent number
US06951884B2

Reaction notes

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