3,5-Bis(trifluoromethyl)benzyl bromide → HCID 22314480, compound

HRID 966086Notes

Reaction equation

HRID 966086 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([OH:10])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[F:11][C:12]([F:26])([F:25])[C:13]1[CH:14]=[C:15]([CH:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:20]=1)[CH2:16]Br>>[F:11][C:12]([F:25])([F:26])[C:13]1[CH:14]=[C:15]([CH:18]=[C:19]([C:21]([F:24])([F:22])[F:23])[CH:20]=1)[CH2:16][O:10][C:8]1[CH:7]=[CH:6][C:3]([C:4]#[N:5])=[C:2]([F:1])[CH:9]=1

Participants

3

Reactant 2

HCID 1225733,5-Bis(trifluoromethyl)benzyl bromideHCID 27346752-Fluoro-4-hydroxybenzonitrile

Product 1

HCID 22314480HCID 22314480, compoundYield 99%

Procedure

As described for example 1a, 2-fluoro-4-hydroxy-benzonitrile (1.5 g, 10.5 mmol) [using 3,5-bis(trifluoromethyl)benzylbromide instead of 3-fluorobenzylbromide] was converted to the title compound (3.8 g, 99%) which was obtained as a white solid. MS: m/e=363.0 (M+).

Sources & evidence

ORD record
ord-cb78753b80e94ca0add2dee787ff4482
Source dataset
uspto-grants-2005_10
Patent number
US06951884B2

Reaction notes

Loading…