HCID 69038838, compound → HCID 22314465, compound

HRID 966089Notes

Reaction equation

HRID 966089 reaction equation
FC1C=C(C=CC=1)C[O:6][C:7](=[O:24])[C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=2)=[C:10]([F:23])[CH:9]=1.FC1C=CC(COC(=O)C2C=CC(OCC3C=CC(F)=CC=3)=C(F)C=2)=CC=1>>[F:23][C:10]1[CH:9]=[C:8]([CH:13]=[CH:12][C:11]=1[O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=1)[C:7]([OH:24])=[O:6]

Participants

3

Reactant 2

HCID 69038838HCID 69038838, compoundHCID 69039983HCID 69039983, compound

Product 1

HCID 22314465HCID 22314465, compoundYield 90%

Procedure

As described for example 18b, 3-fluoro-4-(3-fluoro-benzyloxy)-benzoic acid 3-fluoro-benzyl ester (6.9 g, 18.6 mmol) [instead of 3-fluoro-4-(4-fluoro-benzyloxy)-benzoic acid 4-fluoro-benzyl ester] was converted to the title compound (4.4 g, 90%) which was obtained as a white solid. MS: m/e=263.0 (M+).

Sources & evidence

ORD record
ord-9cba41ed59dc49069090bddbd18bc7e1
Source dataset
uspto-grants-2005_10
Patent number
US06951884B2

Reaction notes

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