1-(Bromomethyl)-4-(trifluoromethyl)benzene → HCID 86759855, compound

HRID 966090Notes

Reaction equation

HRID 966090 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[OH:11])[C:5]([OH:7])=[O:6].[F:12][C:13]([F:23])([F:22])[C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Br)=[CH:16][CH:15]=1>>[F:12][C:13]([F:23])([F:22])[C:14]1[CH:21]=[CH:20][C:17]([CH2:18][O:6][C:5](=[O:7])[C:4]2[CH:8]=[CH:9][C:10]([O:11][CH2:18][C:17]3[CH:16]=[CH:15][C:14]([C:13]([F:12])([F:22])[F:23])=[CH:21][CH:20]=3)=[C:2]([F:1])[CH:3]=2)=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzeneHCID 1604563-Fluoro-4-hydroxybenzoic acid

Product 1

HCID 86759855HCID 86759855, compoundYield 69%

Procedure

As described for example 18a, 3-fluoro-4-hydroxybenzoic acid (2.5 g, 16 mmol) [using 4-(trifluoromethyl)-benzyl bromide instead of 4-fluorobenzyl bromide] was converted to the title compound (5.3 g, 69%) which was obtained as a white solid. MS: m/e=472.1 (M+).

Sources & evidence

ORD record
ord-1fc961466369446d82b3327259edcd40
Source dataset
uspto-grants-2005_10
Patent number
US06951884B2

Reaction notes

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