HCID 69042948, compound → HCID 22314467, compound

HRID 966091Notes

Reaction equation

HRID 966091 reaction equation
FC(F)(F)C1C=CC(C[O:8][C:9](=[O:29])[C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=3)=[C:12](F)[CH:11]=2)=CC=1.[F:34]C(F)(F)C1C=CC(COC(=O)C2C=CC(OCC3C=CC(F)=CC=3)=C(F)C=2)=CC=1>>[F:34][C:11]1[CH:12]=[C:13]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=2)[CH:14]=[CH:15][C:10]=1[C:9]([OH:8])=[O:29]

Participants

3

Reactant 2

HCID 69042948HCID 69042948, compoundHCID 86759855HCID 86759855, compound

Product 1

HCID 22314467HCID 22314467, compoundYield 90%

Procedure

As described for example 18b, 3-fluoro-4-(4-trifluoromethyl-benzyloxy)-benzoic acid 4-trifluoromethyl-benzyl ester (5.3 g, 11 mmol) [instead of 3-fluoro-4-(4-fluoro-benzyloxy)-benzoic acid 4-trifluoromethyl-benzyl ester] was converted to the title compound (3.1 g, 90%) which was obtained as a white solid. MS: m/e=312.9 (M−H−).

Sources & evidence

ORD record
ord-e6141a4899a44f998f032208125e9ad7
Source dataset
uspto-grants-2005_10
Patent number
US06951884B2

Reaction notes

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