Potassium Carbonate → HCID 22314510, compound

Participants

Reaction Steps

A mixture of 3,5-difluorophenol (1 1.0 g, 84.6 mmol), 4-fluorobenzylbromide (16.5 g, 84.6 mmol) and potassium carbonate (12.7 g, 92.2 mmol) in acetone (50 mL) was heated under reflux for 6 h. After cooling to room temperature, the mixture was filtered and the filtrate evaporated. The residue was dissolved in diethyl ether, washed with sodium cabonate (saturated solution), dried over sodium sulfate, filtered and evaporated to leave the title compound (20.8 g, 96%) as a light yellow liquid. MS: m/e=238.1 (M+).

Provenance & Evidence