反应详情

61 g of N-[1,1-dimethyl-2-(2,4,6-trimethylphenyl)ethyl]formamide is refluxed with 35 g of potassium hydroxide in 155 mL ethylene glycol for 9 hours with stirring and, after the reaction has ended, the mixture is poured onto 1 kg of ice. The aqueous phase is extracted three times with diethyl ether and the solvent is distilled off under reduced pressure. The residue is fractionally distilled. Yield: 48 g (89%); bp15: 135° C.-140° C.

1. extractionThe aqueous phase is extracted three times with diethyl ether
2. distillationthe solvent is distilled off under reduced pressure
3. distillationThe residue is fractionally distilled
4. custom135° C.-140° C.