HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-Fluoro-3-nitrobenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-Fluoro-3-nitrobenzoic acid | HCID 67987 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Fluoro-3-nitrobenzoyl chloride | HCID 2783347 | 106.1% |
Reaction Steps
To a solution of 4-fluoro-3-nitrobenzoic acid (20 g, 0.108 mol) in dichloromethane (0.5 L) were added dimethyl formamide (0.1 mL) and oxalyl chloride (47 mL, 0.54 mol) over 20 min. After 1 h, the mixture was concentrated in vacuo to afford the acid chloride, 4-fluoro-3-nitro-benzoyl chloride (23.32 g) as yellow oil which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06951859B2 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-3719a007a6a3441a834754564798c7d1 |
| Source note | uspto-grants-2005_10 |