1-Pyrrolidineethanamine → HCID 22313103, compound

HRID 966148Notes

Reaction equation

[CH3:1][O:2][NH:3][C:4]([C:6]1[CH:7]=[C:8]([NH:13][C:14]2[C:19]3=[C:20]([CH:27]([CH3:29])[CH3:28])[C:21]([C:23]([NH:25][CH3:26])=[O:24])=[CH:22][N:18]3[N:17]=[CH:16][N:15]=2)[CH:9]=[CH:10][C:11]=1[CH3:12])=[O:5].[N:30]1([CH2:35]CN)[CH2:34][CH2:33][CH2:32][CH2:31]1>>[CH3:1][O:2][NH:3][C:4]([C:6]1[CH:7]=[C:8]([NH:13][C:14]2[C:19]3=[C:20]([CH:27]([CH3:29])[CH3:28])[C:21]([C:23]([NH:25][CH2:26][CH2:35][N:30]4[CH2:34][CH2:33][CH2:32][CH2:31]4)=[O:24])=[CH:22][N:18]3[N:17]=[CH:16][N:15]=2)[CH:9]=[CH:10][C:11]=1[CH3:12])=[O:5]

Participants

Reactant 2

HCID 13441-Pyrrolidineethanamine

HCID 10092141HCID 10092141, compound

Product 1

HCID 22313103HCID 22313103, compound

Procedure

Example 19 was prepared from compound A of Example 18 and 2-pyrrolidin-1-yl-ethylamine by a method analogous to the preparation of Example 18 in similar yields LC/MS; (M+H)+=480.4.

Workup

customin similar yields LC/MS

Sources & evidence

ORD record: ord-d335c8089b3e4bdeafe52bc571b1f882
Source dataset: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06951859B2

Reaction notes

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