Triethylamine → HCID 11201236, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of Example 22 (1.11 g, 2.74 mmol) in dioxane (25 mL) was added triethylamine (0.57 mL, 4.1 mmol) followed by diphenylphosphoryl azide (0.77 mL, 3.57 mmol) and the resulting mixture was stirred at 40° C. After 1 h, the mixture was concentrated and the residue was purified by silica gel column chromatography eluting with ethyl acetate in hexanes to afford acyl azide, 4-(2,4-difluoro-5-methoxycarbamoyl-phenylamino)-5-isopropyl-pyrrolo[2, 1-f][1,2,4]triazine-6-carbonyl azide (0.95 g, 81%) as pale yellow foam.

Provenance & Evidence