Ammonia → HCID 137241982, compound

Participants

Reaction Steps

To a solution of compound A of Example 28 (663 mg, 3 mmol) in dimethyl formamide (10 mL) were added were added successively 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (670 mg, 3.5 mmol), HOBt (460 mg, 3 mmol), and triethylamine (0.5 mL, 3.5 mmol). After 2 h, aqueous ammonia (1 mL, 6N) was added. After 1 h, the mixture was concentrated and the residue was partitioned between ethyl acetate (30 mL) and aqueous NaHCO3 (15 mL). The organic layer was separated, dried, and concentrated to afford methyl-5-(1-methylethyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one-6-carboxamide (390 mg, 59%) as white solid. LC/MS; (M+H)+=221.1.

Provenance & Evidence