1,4-Dibromobutane → 6-(4-Bromo-butoxy)-3-(4-fluoro-phenyl)-benzo[d]isothiazole

HRID 966167Notes

Reaction equation

HRID 966167 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH:13]=[CH:14][C:15]([OH:17])=[CH:16][C:11]=3[S:10][N:9]=2)=[CH:4][CH:3]=1.[Br:18][CH2:19][CH2:20][CH2:21][CH2:22]Br>>[Br:18][CH2:19][CH2:20][CH2:21][CH2:22][O:17][C:15]1[CH:14]=[CH:13][C:12]2[C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)=[N:9][S:10][C:11]=2[CH:16]=1

Participants

3

Reactant 2

HCID 80561,4-DibromobutaneHCID 135847953HCID 135847953, compound

Product 1

HCID 223141756-(4-Bromo-butoxy)-3-(4-fluoro-phenyl)-benzo[d]isothiazole

Procedure

In analogy to example 2.1, 3-(4-fluoro-phenyl)-benzo[d]isothiazol-6-ol and 1,4-dibromobutane were converted to yield 6-(4-Bromo-butoxy)-3-(4-fluoro-phenyl)-benzo[d]isothiazole, MS: 379 (M, 1Br).

Sources & evidence

ORD record
ord-4a84b391b69a48fbb0574a639704b418
Source dataset
uspto-grants-2005_10
Patent number
US06951879B2

Reaction notes

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