1,4-Dibromobutane → 6-(4-Bromo-butoxy)-2-methyl-3-(4-trifluoromethyl-phenyl)-benzo[b]thiophene

HRID 966300ノート

反応式

HRID 966300 の反応式
[CH3:1][C:2]1[S:6][C:5]2[CH:7]=[C:8]([OH:11])[CH:9]=[CH:10][C:4]=2[C:3]=1[C:12]1[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=1.[Br:22][CH2:23][CH2:24][CH2:25][CH2:26]Br>>[Br:22][CH2:23][CH2:24][CH2:25][CH2:26][O:11][C:8]1[CH:9]=[CH:10][C:4]2[C:3]([C:12]3[CH:13]=[CH:14][C:15]([C:18]([F:21])([F:19])[F:20])=[CH:16][CH:17]=3)=[C:2]([CH3:1])[S:6][C:5]=2[CH:7]=1

参加物

3

反応物 2

HCID 80561,4-DibromobutaneHCID 179328792-Methyl-3-(4-trifluoromethyl-phenyl)-benzo[b]thiophen-6-ol

生成物 1

HCID 223141486-(4-Bromo-butoxy)-2-methyl-3-(4-trifluoromethyl-phenyl)-benzo[b]thiophene

実験手順

In analogy to example 27.1, 2-Methyl-3-(4-trifluoromethyl-phenyl)-benzo[b]thiophen-6-ol and 1,4-dibromobutane were converted to yield 6-(4-Bromo-butoxy)-2-methyl-3-(4-trifluoromethyl-phenyl)-benzo[b]thiophene as colorless oil, MS: 443 (MH+, 1Br).

出典と根拠

ORDレコード
ord-d241123045aa4247bd3a2a1ec7e7a6b5
出典データセット
uspto-grants-2005_10
特許番号
US06951879B2

反応ノート

読み込み中…