Ethylamine → HCID 59107263, compound

Participants

Reaction Steps

A compound having a structure of the above formula was prepared where the substituent R1 is —CH2CH3, R2 is hydrogen, and R3 is 4-nitrobenzyl (—CH2(4-nitro)C6H4). The compound (C19H22N6O7) was prepared by reaction of ethylamine with 6-chloro-2-(4-nitrobenzyl)oxy-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine (Example 4) as described in Example 2, Step E. The final product was isolated in 60% yield as a solid with a melting point of 210-213° C. 1H-NMR (DMSO-d6): δ 1.05 (1, 3H, J=8); 3.4 (m, 2H); 3.5 (m, 1H); 3.6 (m, 1H); 3.85 (m, 1H); 4.05 (m, 1H); 4.6 (m, 1H); 5.2 (m, 2H); 5.4 (d, 1H, J=6); 5.45 (s, 2H); 5.8 (d, 1H, J=6); 7.8 (d, 2H, J=8); 8 (bt, 1H); 8.2 (s, 1H); 8.25 (d, 2H, J=8).

Provenance & Evidence