Ammonia → HCID 59107261, compound

Participants

Reaction Steps

A compound having a structure of the above formula was prepared where the substituents R1 and R2 are hydrogen and R3 is 4-nitrobenzyl (—CH2(4-nitro)C6H4). The compound (C17H18N6O7) was prepared by reaction of ammonia with 6-chloro-2-(4-nitrobenzyl)oxy-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine (Example 4) as described in Example 2, Step E. The final product was isolated in 80% yield as a solid with a melting point of 174-176° C. 1H-NMR (DMSO-d6): δ 3.5 (m, 1H); 3.6 (m, 1H); 3.8 (d, 1H, J=4); 4.1 (m, 1H); 4.56 (m, 1H); 5.16 (m, 2H); 5.4 (d, 1H, J=6); 5.47 (s, 2H); 5.77 (d, 1H, J=6); 7.43 (bs, 2H); 7.7 (d, 2H, J=8); 8.18 (s, 1H); 8.24 (d, 2H, J=8).

Provenance & Evidence