Ammonia → HCID 59107257, compound

Participants

Reaction Steps

A compound having a structure of the above formula was prepared where the substituents R1 and R2 are hydrogen and R3 is —CH2COOH. The compound (C12H15N5O7) was prepared by reaction of ammonia with (6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuran-osyl)purin-2-yl)oxyacetic acid tert-butyl ester (Example 6) as described in Example 2, Step E. The final product was isolated in 70% yield as a solid with a melting point of 200-203° C. 1H-NMR (DMSO-d6): δ 3.4 (m, 1H); 3.55 (m, 1H); 3.91 (m, 1H); 4.11 (m, 1H); 4.56 (m, 1H); 4.74 (bs, 1H); 4.78 (s, 2H); 5.3 (bs, 2H); 5.75 (d, 1H, J=6); 7.36 (bs, 2H); 8.15 (s, 1H); 12.6 (bs, 1H).

Provenance & Evidence