Ammonia → HCID 59107258, compound

Participants

Reaction Steps

A compound having a structure of the above formula was prepared where the substituents R1 and R2 are hydrogen and R3 is —CH2CH2CH2(3-OCH3)C6H4. The compound (C20H25N5O6) was prepared by reaction of ammonia with 6-chloro-2-[3-(3-methoxyphenyl)propyloxy]-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine (Example 7) as described in Example 2, Step E. The final product was isolated in 10% yield as a solid with a melting point of 85-87° C. 1H-NMR (DMSO-d6): 1.97 (t, 2H, J=6); 2.69 (t, 2H, J=6); 3.54 (m, 2H); 3.71 (s, 3H); 3.95 (m, 1H); 4.15 (m, 3H); 4.58 (m, 1H); 5.19 (m, 2H); 5.42 (d, 1H, J=6); 5.77 (d, 1H, J=6); 6.77 (m, 3H); 7.19 (t, 1H, 8); 7.3 (bs, 2H); 8.14 (s, 1H).

Provenance & Evidence