Potassium Carbonate → HCID 178504708, compound

Participants

Reaction Steps

A mixture of acetoxyhydroamic acid (27 mg, 2.5eq) and K2CO3 (98 mg, 5eq) in DMF/H2O (3:1, 4 ml) was stirred at room temperature for 20 min. To this mixture was added 2-fluoro-5-[1-(3-fluoro-2′-methanesulfonyl-biphenyl-4-yl)-2-oxo-piperidin-3-ylamino]-benzonitrile (68 mg, 0.141 mmol) prepared as described under Ex. 58a above. The whole was stirred and heated at 110° C. for 18 h. The mixture was diluted with water and extracted 3× with EtOAc. The combined organic extracts were washed with brine, dried over MgSO4, filtered and evaporated. Purification by reverse phase HPLC yielded the title compound (50 mg, 72%) 1H NMR (DMSO-d6) δ 8.11 (1H,d,J=8 Hz), 7.79 (1H,t,J=7, 3 Hz), 7.71 (1H,t,J=7, 73 Hz), 7.46 (2H,m), 7.37 (1H,d,J=11 Hz), 7.28 (1H,d,J=8 Hz), 7.18 (1H,t,J=9.5 Hz), 6.98 (1H,m), 6.85 (1H,m), 4.29 (1H,m), 3.72 (2H,t,J=6.2 Hz), 2.91 (3H,s), 2.28 (1H,m), 2.08 (2H,m), 1.84 (1H,m). MS 515.3 (M+H)+.

Provenance & Evidence