Hydrochloric Acid → 5-(2-Amino-ethyl)-2-methyl-1H-indole-3-carboxylic Acid Benzyl Ester Hydrochloride

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Reaction Steps

To a solution of 5-(2-tert-butoxycarbonylamino ethyl)-2-methyl-1H-indole-3-carboxylic acid benzyl ester (1.972 g, 4.827 mmol) in dioxane (25 mL) at room temperature was added aqueous HCl (3.0 mL, 37%). The resulting mixture was then stirred at ambient temperature for 22 hours. After this duration, the mixture was concentrated in vacuo. Trituration with acetone gave 1.48 g (89%) of the desired product as a white solid, mp 282-283° C.; MS (APCI+): m/z 309.0 (M+1).

Provenance & Evidence