Hydrazine → 370107-78-1

HRID 966944Notes

Reaction equation

HRID 966944 reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[CH2:7][CH2:8][CH2:9][N:10]1C(=O)C2=CC=CC=C2C1=O.NN>C(Cl)(Cl)Cl>[NH2:10][CH2:9][CH2:8][CH2:7][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][N:1]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 22292750HCID 22292750, compound

Product 1

HCID 22292749370107-78-1Yield 90%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

N-[3-(2-Pyrazinyl)propyl]phthalimide (521 mg, 1.95 mmol) was dissolved in chloroform (15 mL) followed by addition of anhydrous hydrazine (1.5 mL), and then the mixture was stirred at room temperature for 20 hours. The resulting precipitate was removed by filtration, and the filtrate was washed with water and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and 2-(3-aminopropyl)pyrazine (240 mg; yield 90%) was thus obtained.

Workup

  1. customThe resulting precipitate was removed by filtration
  2. washthe filtrate was washed with water
  3. dry with materialdried over anhydrous sodium sulfate

Sources & evidence

ORD record
ord-9ce6b49e5a90408284179b193747c0f3
Source dataset
uspto-grants-2005_10
Patent number
US06953785B2

Reaction notes

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