Propargyl bromide → 2-(ethoxymethyl)-1-[2-(prop-2-ynyloxy)ethyl]-1H-imidazo[4,5-c]quinoline

Participants

Role	Name	HCID	Charge
Reactant	Propargyl bromide	HCID 7842	—
Reactant	2-[2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]ethanol	HCID 13007355	—
Product	2-(ethoxymethyl)-1-[2-(prop-2-ynyloxy)ethyl]-1H-imidazo[4,5-c]quinoline	HCID 22254479	101%

Reaction Steps

Using the general method of Example 1 Part A 2-[2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]ethanol (1.39 g, 5.123 mmol) was reacted with propargyl bromide (80% in toluene, 1.7 mL, 15.37 mmol) to provide 1.6 g of 2-(ethoxymethyl)-1-[2-(prop-2-ynyloxy)ethyl]-1H-imidazo[4,5-c]quinoline as an oil.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06953804B2
Source dataset	uspto-grants-2005_10
ORD ID	ord-25ba46e8f13b464989acfcc16cd07f3e
Source note	uspto-grants-2005_10