Acetic Anhydride → HCID 22310834, compound

Participants

Reaction Conditions

Reaction Steps

Methyl N-(3,4-dichlorobenzyl)-5-aminoindole-2-carboxylate (0.28 g) was dissolved in acetic anhydride and heated to 90° C. for 1 hour. Upon cooling, the title compound crystallised as white needles, was filtered off, washed with diethyl ether and dried in vacuo to yield the desired end product (0.1 g, 32%); NMR δ (CD3SOCD3) 2.03 (s, 3H), 3.80 (s, 3H), 5.80 (s, 2H), 6.88 (in, 1H), 7.36 (in, 3H), 7.52 (d, 2H), 8.08 (s, 1H), 9.88 (s, 1H); M/z (−) 391 (M+), 389.

Provenance & Evidence