HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 967111Generated: October 31, 2026
Acetic Anhydride → Methyl 4-acetoxyindole-2-carboxylate
https://huagongshe.com/reaction/967111
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Methyl 4-hydroxy-1H-indole-2-carboxylate | HCID 22310940 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | Methyl 4-acetoxyindole-2-carboxylate | HCID 22310858 | — |
Reaction Steps
Methyl 4-hydroxyindole-2-carboxylate (0.5 g) and 4-dimethylaminopyridine (50 mg) were dissolved in acetic anhydride (5 ml) and heated at 80° C. for 3 hours. The reaction was allowed to cool overnight to precipitate white crystals, which were filtered and dried in vacuo (0.44 g, 72%); NMR δ (CD3SOCD3) 2.34 (s, 3H), 3.85 (s, 3H), 6.80 (d, 1H), 7.06 (s, 1H), 7.23 (t, 1H), 7.29-7.35 (m, 1H), 12.1 (bs, 1H); M/z (−) 232 (M−H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06953809B2 |
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| Source dataset | uspto-grants-2005_10 |
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| ORD ID | ord-91fcb033532a4634b61fc9e69f0abe6f |
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| Source note | uspto-grants-2005_10 |
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