HCID 86590033, compound → HCID 178484010, compound

Participants

Reaction Steps

1.15 g (3.07 mmol) trans-E/Z-[4-(5-bromo-pent-1-enyl)-cyclohexylmethyl]-methyl-carbamic acid tert-butyl ester dissolved in 15 ml of ethanol were added to a suspension of 300 mg platinum dioxide freshly reduced to platinum by hydrogenation immediately prior to use. Hydrogenation was then continued at ambient pressure until 95% of the calculated amount of hydrogen had been consumed. Then, the reaction mixture was filtered over celite and evaporated giving 0.950 g (82%) trans-[4-(5-bromo-pentyl)-cyclohexylmethyl]-methyl-carbamic acid tert-butyl ester as colorless viscous oil, MS: 375 (M+, 1Br).

Provenance & Evidence