HCID 178484015, compound → HCID 178484017, compound

Participants

Reaction Conditions

Reaction Steps

1.22 g (3.0 mmol) trans-N-[4-(4-hydroxy-butyl)-cyclohexylmethyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide were dissolved in 4.0 ml of pyridine, cooled to −10° C. and treated with 0.687 g methanesulfochloride. The reaction mixture was then stirred at room temperature for 2 hours. It was subsequently poured into 50 ml of an ice/water/diluted hydrogen chloride mixture and extracted 3 times with 50 ml of dichloromethane. The combined dichloromethane phases were dried over magnesium sulfate and evaporated under reduced pressure giving 1.35 g (92.8%) trans-methanesulfonic acid 4-(4-{[methyl-(4-trifluoromethyl-benzenesulfonyl)-amino]-methyl}-cyclohexyl)-butyl ester as colorless solid, MS: 486 (MH+).

Provenance & Evidence