4-Trifluoromethyl-benzene sulfochloride → HCID 178484051, compound

HRID 967131Notes

Reaction equation

HRID 967131 reaction equation
[CH3:1][NH:2][CH2:3][C@H:4]1[CH2:9][CH2:8][C@H:7]([CH2:10][OH:11])[CH2:6][CH2:5]1.[S:12](Cl)([OH:15])(=O)=[O:13].[F:17][C:18]([F:26])([F:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[OH:11][CH2:10][C@H:7]1[CH2:8][CH2:9][C@H:4]([CH2:3][N:2]([CH3:1])[S:12]([C:22]2[CH:23]=[CH:24][C:19]([C:18]([F:26])([F:25])[F:17])=[CH:20][CH:21]=2)(=[O:15])=[O:13])[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 222941704-Trifluoromethyl-benzene sulfochlorideHCID 178484044HCID 178484044, compound

Product 1

HCID 178484051HCID 178484051, compound

Procedure

In analogy to the procedure described in examples 1.6, trans-(4-methylaminomethyl-cyclohexyl)-methanol (example 1.1) was acylated with 4-trifluoromethyl-benzene sulfochloride giving trans-N-(4-hydroxymethyl-cyclohexylmethyl)-N-methyl-4-trifluoromethyl-benzenesulfonamide as colorless solid, MS: 366 (MH+).

Sources & evidence

ORD record
ord-11bf845b80c845f0bee69cf675fcfac9
Source dataset
uspto-grants-2005_10
Patent number
US06953806B2

Reaction notes

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