Methanesulfonyl chloride → HCID 178484090, compound

HRID 967132Notes

Reaction equation

[OH:1][CH2:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([CH2:9][N:10]([CH3:24])[S:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)(=[O:13])=[O:12])[CH2:5][CH2:4]1.[CH3:25][S:26](Cl)(=[O:28])=[O:27]>>[CH3:24][N:10]([CH2:9][C@H:6]1[CH2:7][CH2:8][C@H:3]([CH2:2][O:1][S:26]([CH3:25])(=[O:28])=[O:27])[CH2:4][CH2:5]1)[S:11]([C:14]1[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:21])[F:22])=[CH:16][CH:15]=1)(=[O:13])=[O:12]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 178484051HCID 178484051, compound

Product 1

HCID 178484090HCID 178484090, compound

Procedure

In analogy to the procedure described in example 3.4, trans-N-(4-hydroxymethyl-cyclohexylmethyl)-N-methyl-4-trifluoromethyl-benzenesulfonamide is treated with methanesulfonyl chloride to yield trans-methanesulfonic acid 4-{[methyl-(4-trifluoromethyl-benzenesulfonyl)-amino]-methyl}-cyclohexylmethyl ester as colorless solid, MS: 443 (M+).

Sources & evidence

ORD record: ord-ec7ae35a353d4be58415388ffb6fc353
Source dataset: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06953806B2

Reaction notes

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