4-Chlorophenyl chloroformate → HCID 178484045, compound

HRID 967133Notes

Reaction equation

HRID 967133 reaction equation
[CH3:1][NH:2][CH2:3][C@H:4]1[CH2:9][CH2:8][C@H:7]([CH2:10][OH:11])[CH2:6][CH2:5]1.Cl[C:13]([O:15][C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=1)=[O:14]>>[Cl:22][C:19]1[CH:20]=[CH:21][C:16]([O:15][C:13](=[O:14])[N:2]([CH2:3][C@H:4]2[CH2:9][CH2:8][C@H:7]([CH2:10][OH:11])[CH2:6][CH2:5]2)[CH3:1])=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 1390594-Chlorophenyl chloroformateHCID 178484044HCID 178484044, compound

Product 1

HCID 178484045HCID 178484045, compound

Procedure

In analogy to the procedure described in examples 1.7, trans-(4-methylaminomethyl-cyclohexyl)-methanol (example 1.1) was acylated with 4-chlorophenyl chloroformate [Org. Lett. (2000), 2(8), 1049-1051] giving trans-(4-hydroxymethyl-cyclohexylmethyl)-methyl-carbamic acid 4-chloro-phenyl ester as colorless viscous oil, MS: 311 (M+).

Sources & evidence

ORD record
ord-ebc7f34d946d45599a4dee9e1f1b17f7
Source dataset
uspto-grants-2005_10
Patent number
US06953806B2

Reaction notes

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