Methanesulfonyl chloride → HCID 178484089, compound

HRID 967134Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9](=[O:21])[N:10]([CH2:12][C@H:13]2[CH2:18][CH2:17][C@H:16]([CH2:19][OH:20])[CH2:15][CH2:14]2)[CH3:11])=[CH:4][CH:3]=1.[CH3:22][S:23](Cl)(=[O:25])=[O:24]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][C:9]([N:10]([CH2:12][C@H:13]2[CH2:18][CH2:17][C@H:16]([CH2:19][O:20][S:23]([CH3:22])(=[O:25])=[O:24])[CH2:15][CH2:14]2)[CH3:11])=[O:21])=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 178484045HCID 178484045, compound

Product 1

HCID 178484089HCID 178484089, compound

Procedure

In analogy to the procedure described in example 3.4, the trans-(4-hydroxymethyl-cyclohexylmethyl)-methyl-carbamic acid 4-chloro-phenyl ester was treated with methanesulfonyl chloride to yield trans-methanesulfonic acid 4-{[(4-chloro-phenoxycarbonyl)-methyl-amino]-methyl}-cyclohexylmethyl ester as colorless viscous oil, MS: 390 (MH+).

Sources & evidence

ORD record: ord-5e7f8649a08c4b8c80f870494de708c3
Source dataset: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06953806B2

Reaction notes

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